11/21/2017. (2018), Dugar G, Leenay RT, Eisenbart SK, Bischler T, Aul BU, Beisel CL, Sharma CM From an engineering perspective, each discovery creates the opportunity to develop new technologies to improve how we gauge our health and treat diseases that afflict us. (2018), Beisel CL In 2018, Beisel moved from the Department of Chemical and Biomolecular Engineering at the North Carolina State University in Raleigh (USA) to the HIRI in Würzburg, where he has been the head of the “RNA Synthetic Biology” research group for two years now. These systems use RNA to recognize matching genetic material from selfish genetic elements bent on infecting these microbes. E: [email protected] The most Beisel families were found in the USA in 1880. CRISPR technologies hold incredible potential, yet they are derived from immune systems that we are still trying to understand. RNA is a ubiquitous molecule of life that plays intimate roles in how cells function and make decisions. (2008), Beisel CL, Dowd MK, Reilly PJ and his PhD in chemical engineering from the California Institute of Technology, and he held a postdoctoral fellowship in bacterial genetics at the National Institutes of Health (NIH). (2017), Current Opinion in Microbiology, 38: 156-164, Marshall R, Maxwell CS, Collins SP, Beisel CL, Noireaux V doi: 10.1128/AEM.02312-19. Learn more about research in the Chase Beisel Lab. (2018), Maxwell CS, Jacobsen T, Marshall R, Noireaux V, Beisel CL (2017), Current Opinion in Biomedical Engineering, 4: 57-64, Luo ML, Jackson RN, Denny SR, Tokmina-Lukaszewska M, Maksimchuk KR, Lin W, Bothner B, Wiedenheft B, Beisel CL Wang Young Investigator Award through the Journal of Biotechnology & Bioengineering. (2019), Martino ME, Joncour P, Leenay R, Gervais H, Shah M, Hughes S, Gillet B, Beisel CL, Leulier F Our group has focused on understanding and engineering CRISPR-Cas systems. Pennsylvania had the highest population of Beisel families in 1840. Image credit: Beisel Lab/HIRI Press contact. The lab of Prof Chase Beisel (formerly North Carolina State University, USA) will investigate and harness the functional diversity of CRISPR-Cas immune systems for the development of new foundational technologies. Prof. Dr. Chase Beisel, HIRI, Würzburg Functional characterization of extensively self-targeting CRISPR-Cas systems in the bacterial plant pathogen Xanthomonas albilineans Homepage Beisel Laboratory. (2020), Applied and Environmental Microbiology, 86 (7): 02312-19, Beisel CL (2010), FEMS Microbiology Reviews, 34 (5): 866-82, Bayer TS, Hoff KG, Beisel CL, Lee JJ, Smolke CD Our group is based in the Department of Chemical and Biomolecular Engineering at North Carolina State University. The RNA synthetic biology group aims to better understand the roles RNA plays in biology and to exploit these roles to improve how we study, diagnose, and treat infectious diseases in humans. Congrats to the two first authors, Ryan Marshall and Colin Maxwell, the scientists at Benson Hill Biosystems, and the other contributing members of the Beisel group (Scott, Tom, Michelle)! ↵ † Corresponding author. 5 Faculty of Medicine, University of Würzburg, 97078 Würzburg, Germany. 1. 2055 Concession 12. (2018), Bober JR, Beisel CL, Nair NU Dr. Beisel received his BS in chemical engineering from Iowa State Univ. (2018), Liao C, Slotkowski RA, Achmedov T, Beisel CL ... Movie presentation followed by a discussion with HIRI scientists Jörg Vogel and Chase Beisel. (2017), Leenay RT, Beisel CL We are interested in understanding and engineering CRISPR-Cas systems. We are exploring the full diversity of these immune systems in nature and how their functions have evolved to protect microbes against foreign invaders. (2019), Liao C, Slotkowski RA, Beisel CL Part 1, Deciphering, Communicating, and Engineering the CRISPR PAM, Toward a genetic tool development pipeline for host-associated bacteria, Short DNA containing χ sites enhances DNA stability and gene expression in E. coli cell-free transcription-translation systems, Advancing the design and delivery of CRISPR antimicrobials, The CRISPR RNA-guided surveillance complex in Escherichia coli accommodates extended RNA spacers, Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems, Rethinking the Hierarchy of Sugar Utilization in Bacteria, Current and future prospects for CRISPR-based tools in bacteria, Efficient Delivery of CRISPR-Cas9 for Genome Editing via Self-Assembled DNA Nanoclews**, Trade-offs in engineering sugar utilization pathways for titratable control, Impact of Residual Inducer on Titratable Expression Systems, Repurposing endogenous type I CRISPR-Cas systems for programmable gene repression, A CRISPR design for next-generation antimicrobials, Guide RNA functional modules direct Cas9 activity and orthogonality, Construction of ligand-responsive microRNAs that operate through inhibition of Drosha processing, Bacterial sugar utilization gives rise to distinct single-cell behaviours, Programmable removal of bacterial strains by use of genome-targeting CRISPR-Cas systems, Understanding and exploiting feedback in synthetic biology, Multiple factors dictate target selection by Hfq-binding small RNAs, The base pairing RNA Spot 42 participates in a multi-output feedforward loop to help enact catabolite repression in Escherichia coli, Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing, Discriminating tastes: physiological contributions of the Hfq-binding small RNA Spot 42 to catabolite repression, Base pairing small RNAs and their roles in global regulatory networks, Synthetic control of a fitness tradeoff in yeast nitrogen metabolism, Design Principles for Riboswitch Function, Model-guided design of ligand-regulated RNAi for programmable control of gene expression, Conformational analysis of gossypol and its derivatives by molecular mechanics, Cochlear whole mount in situ hybridization: identification of longitudinal and radial gradients.

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